Mixtard 30/Mixtard 30 Penfill Dosage/Direction for Use

Mixtard is a dual-acting insulin. It is a biphasic formulation containing both fast-acting and long-acting insulin. Premixed insulin products are usually given once or twice daily when a rapid initial effect together with a more prolonged effect is desired.
Dosage: Dosage is individual and determined in accordance with the needs of the patient. The individual insulin requirement is usually between 0.3 and 1.0 IU/kg/day. The daily insulin requirement may be higher in patients with insulin resistance (e.g. during puberty or due to obesity) and lower in patients with residual, endogenous insulin production.
An injection should be followed within 30 minutes by a meal or snack containing carbohydrates.
Dosage adjustment: Concomitant illness, especially infections and feverish conditions, usually increases the patient's insulin requirement. Concomitant diseases in the kidney, liver or affecting the adrenal, pituitary or thyroid gland can require changes in the insulin dose. Adjustment of dosage may also be necessary if patients change physical activity or their usual diet. Dosage adjustment may be necessary when transferring patients from one insulin preparation to another.
Administration: For subcutaneous use. Insulin suspensions are never to be administered intravenously.
Mixtard is administered subcutaneously in the thigh or abdominal wall. If convenient, the gluteal region or the deltoid region may also be used.
Subcutaneous injection into the abdominal wall ensures a faster absorption than from other injection sites.
Injection into a lifted skin fold minimises the risk of unintended intramuscular injection. The needle should be kept under the skin for at least 6 seconds to make sure the entire dose is injected. Injection sites should always be rotated within the same region in order to reduce the risk of lipodystrophy.
Mixtard is accompanied by a package leaflet with detailed instructions for use to be followed.
Mixtard 30: Mixtard vials are for use with insulin syringes with a corresponding unit scale.
Mixtard 30 Penfill: Mixtard Penfill is designed to be used with Novo Nordisk delivery systems and NovoFine or NovoTwist needles.